Iron, magnesium, inflammation – how do they relate?

Morley has shared before in his MAG-pie alert #3 about the relationship between iron and mag, but the connection may not have been fully obvious unless you read on. 

This quote from the paper he mentions gives you a little insight…

“This key feature leads us to postulate that when iron accumulates, chelatable iron replaces magnesium at the corresponding metal-binding site, promoting selective damage to these proteins.” 
Source: https://www.ncbi.nlm.nih.gov/pubmed/18280258/

Chelate just means bonds between things – so when there is an accumulation of iron, it can end up bonding to the same sites as magnesium should be present at.
Magnesium – has two electrons to donate… (source)


Iron – also has two electrons to donate…(source)

So, when we consider Morley’s quoted figure of 3,571 proteins in the body that require magnesium to do their work… if iron accumulates in these positions within proteins and this damages them…what do you think that means for those proteins? They can no longer work. 

What about those individuals who get more and more build up of iron from the excesses in our food and environment? Less and less places for magnesium to be stored and bonded to proteins, and more and more inflammation to be present within the body.

The proteins cannot do their job and the body will switch off the functions and over time, go more and more into survival mode. This may be activating gene mutations (have you heard of mthfr?) or could be reactions happening to food or the environment, auto-immune conditions like diabetes, or so many other things. 

If there isn’t sufficient magnesium, then inflammation becomes more and more prevalent. 

Places where iron are stored and normally wouldn’t have it, also are irritated and inflamed. But now there’s insufficient magnesium to offset it, so chronic inflammation sets in. 

Consider this – relocate the excess iron outside of the body, or to places it’s needed inside the body (by building Ceruloplasmin in the blood), providing enough magnesium to build up stores, not just maintain levels, and to stop adding extra iron from non-food sources (which make the situation worse). 

But my iron results are always low?

Are they? Have you been told you have anaemia, low ferritin or low hemaglobin? Have you supplemented with iron yet it never goes up?

Do you understand what your results actually mean?

The more you supplement, the more it doesn’t seem to help (or to ‘last’), so the more medications you need to be on to support the new diagnoses you are constantly getting?

Does your healthcare professional understand what ceruloplasmin is and how critical it is? 

Have they tested your full iron panel, serum copper, serum ceruloplasmin, RBC Magnesium and understand how they relate? Do they take the time to explain it to you and discuss?

If the answer is no, maybe you should consider watching the video of Morley Robbins on his website

Get the right testing, empower yourself and don’t just blindly take things without understanding what is going on. 

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